| Date | Time | At | Opponent | Location | TV | Tournament | Result |
|---|---|---|---|---|---|---|---|
| October 29 (Saturday) |
3:00 PM | Home | Marian University | Bloomington, Ind. | Exhibition | W 78-42 | |
| November 3 (Thursday) |
7:00 PM | Home | Saint Francis | Bloomington, Ind. | Exhibition | W 104-59 | |
| November 7 (Mon) |
7:00 PM | Home | Morehead State | Bloomington, Ind. | W 88-53 | ||
| November 10 (Thursday) |
8:30 PM | Home | Bethune-Cookman | Bloomington, Ind. | W 101-49 | ||
| November 18 (Friday) |
6:00 PM | Away | Xavier | Cincinnati, Ohio | FS1 | ||
| November 20 (Sunday) |
5:30 PM | Neutral | Miami (OH) | Indianapolis, Ind. | BTN | ||
| November 23 (Wednesday) |
6:30 PM | Home | Little Rock | Bloomington, Ind. | BTN | ||
| November 25 (Friday) |
12:30 PM | Home | Jackson State | Bloomington, Ind. | BTN | ||
| November 30 (Wednesday) |
9:15 PM | Home | North Carolina | Bloomington, Ind. | ESPN | ||
| December 3 (Saturday) |
4:00 PM | Away | Rutgers | Piscataway, N.J. | BTN | ||
| December 7 (Wednesday) |
8:30 PM | Home | Nebraska | Bloomington, Ind. | BTN | ||
| December 10 (Saturday) |
7:30 PM | Neutral | Arizona | Las Vegas, Nev. | FOX | ||
| December 17 (Saturday) |
Noon | Away | Kansas | Lawrence, Kan. | ESPN2 | ||
| December 20 (Tuesday) |
7:00 PM | Home | Elon | Bloomington, Ind. | BTN | ||
| December 23 (Friday) |
7:00 PM | Home | Kennesaw State | Bloomington, Ind. | BTN | ||
| January 5 (Thursday) |
9:00 PM | Away | Iowa | Iowa City, Iowa | FS1 | ||
| January 8 (Sunday) |
Noon | Home | Northwestern | Bloomington, Ind. | FS1 | ||
| January 11 (Wednesday) |
7:00 PM | Away | Penn State | University Park, Pa. | BTN | ||
| January 14 (Saturday) |
1:00 PM | Home | Wisconsin | Bloomington, Ind. | CBS | ||
| January 19 (Thursday) |
8:30 PM | Away | Illinois | Champaign, Ill. | FS1 | ||
| January 22 (Sunday) |
Noon or 1:00 PM |
Home | Michigan State | Bloomington, Ind. | CBS | ||
| January 25 (Wednesday) |
9:00 PM | Away | Minnesota | Minneapolis, Minn. | BTN | ||
| January 28 (Saturday) |
8:00 PM | Home | Ohio State | Bloomington, Ind. | Fox | ||
| January 31 (Tuesday) |
9:00 PM | Away | Maryland | College Park, Md. | ESPN/2 | ||
| February 4 (Saturday) |
4:00 PM | Home | Purdue | Bloomington, Ind. | ESPN/2 | ||
| February 7 (Tuesday) |
6:30 PM | Home | Rutgers | Bloomington, Ind. | BTN | ||
| February 11 (Saturday) |
6:00 PM | Away | Michigan | Ann Arbor, Mich. | ESPN | ||
| February 15 (Wednesday) |
9:00 PM | Away | Northwestern | Evanston, Ill. | BTN | ||
| February 18 (Saturday) |
Noon | Home | Illinois | Bloomington, Ind. | ESPN/2 | ||
| February 21 (Tuesday) |
9:00 PM | Away | Michigan State | East Lansing, Mich. | ESPN/2 | ||
| February 25 (Saturday) |
7:30 PM | Away | Purdue | West Lafayette, Ind. | Fox | ||
| February 28 (Tuesday) |
7:00 PM | Home | Iowa | Bloomington, Ind. | ESPN/2 | ||
| March 5 (Sunday) |
4:30 PM | Home | Michigan | Bloomington, Ind. | CBS | ||
| March 8 (Wednesday) |
TBA | Neutral | 2023 Big Ten Men’s Basketball Tournament |
Chicago, Ill. |