| Date | Time | At | Opponent | Location | TV | Tournament | Result | Rank |
|---|---|---|---|---|---|---|---|---|
| November 2, 2022 (Wednesday) |
7 PM | Home | Truman State | West Lafayette, Ind. | B1G+ | Exhibition | W, 102-57 | |
| November 8, 2022 (Tuesday) |
6:30 PM | Home | Milwaukee | West Lafayette, Ind. | BTN | W, 84-53 | ||
| November 11, 2022 (Friday) |
7 PM | Home | Austin Peay | West Lafayette, Ind. | BTN | W, 63-44 | ||
| November 15, 2022 (Tuesday) |
8:30 PM | Home | Marquette | West Lafayette, Ind. | FS1 | Gavitt Games | W, 75-70 | |
| November 24, 2022 (Thursday) |
10 PM | Neutral | West Virginia | Portland, Ore. | ESPN2 | Phil Knight Legacy |
W, 80-68 | 24 |
| November 25, 2022 (Friday) |
9 PM | Neutral | (6) Gonzaga | Portland, Ore. | TBA | Phil Knight Legacy |
W, 84-66 | 24 |
| November 27, 2022 (Sunday) |
TBA | Neutral | (8) Duke | Portland, Ore. | TBA | Phil Knight Legacy |
W, 75-56 | 24 |
| November 30, 2022 (Wednesday) |
7:15 PM | Away | Florida State | Tallahassee, Fla. | ESPN2 / ESPNU |
ACC / Big Ten Challenge |
W, 79-69 | 5 |
| December 4, 2022 (Sunday) |
5 PM | Home | Minnesota | West Lafayette, Ind. | BTN | W, 89-70 | 5 | |
| December 7, 2022 (Wednesday) |
7 PM | Home | Hofstra | West Lafayette, Ind. | B1G+ | W, 85-66 | 4 | |
| December 10, 2022 (Saturday) |
2:15 PM | Away | Nebraska | Lincoln, Neb. | BTN | W, 65-62 (OT) |
4 | |
| December 17, 2022 (Saturday) |
6:15 PM | Neutral | Davidson | Indianapolis, Ind. | BTN | Indy Classic | W, 69-61 | 1 |
| December 21, 2022 (Wednesday) |
9 PM | Home | New Orleans | West Lafayette, Ind. | ESPNU | W, 74-53 | 1 | |
| December 29, 2022 (Thursday) |
5 PM | Home | Florida A&M | West Lafayette, Ind. | BTN | W, 82-49 | 1 | |
| January 2, 2023 (Monday) |
12 PM | Home | Rutgers | West Lafayette, Ind. | BTN | L, 65-64 | 1 | |
| January 5, 2023 (Thursday) |
7 PM | Away | (24) Ohio State | Columbus, Ohio | FS1 | W, 71-69 | 1 | |
| January 8, 2023 (Sunday) |
6 PM | Neutral | Penn State | Philadelphia, Pa. / The Palestra |
BTN | |||
| January 13, 2023 (Friday) |
7 PM | Home | Nebraska | West Lafayette, Ind. | BTN | |||
| January 16, 2023 (Monday) |
2:30 PM | Away | Michigan State | East Lansing, Mich. | FOX | |||
| January 19, 2023 (Thursday) |
7 PM | Away | Minnesota | Minneapolis, Minn. | ESPN / ESPN2 |
|||
| January 22, 2023 (Sunday) |
1 or 2 PM | Home | Maryland | West Lafayette, Ind. | FS1 | |||
| January 26, 2023 (Thursday) |
9 PM | Away | Michigan | Ann Arbor, Mich. | FS1 | |||
| January 29, 2023 (Sunday) |
12:15 PM | Home | Michigan State | West Lafayette, Ind. | CBS | |||
| February 1, 2023 (Wednesday) |
6:30 PM | Home | Penn State | West Lafayette, Ind. | BTN | |||
| February 4, 2023 (Saturday) |
4 PM | Away | Indiana | Bloomington, Ind. | ESPN / ESPN2 |
|||
| February 9, 2023 (Thursday) |
7 PM | Home | Iowa | West Lafayette, Ind. | ESPN2 | |||
| February 12, 2023 (Sunday) |
2 PM | Away | Northwestern | Evanston, Ill. | BTN | |||
| February 16, 2023 (Thursday) |
6:30 PM | Away | Maryland | College Park, Md. | BTN | |||
| February 19, 2023 (Sunday) |
1 PM | Home | Ohio State | West Lafayette, Ind. | CBS | |||
| February 25, 2023 (Saturday) |
7:30 PM | Home | Indiana | West Lafayette, Ind. | FOX | |||
| March 2, 2023 (Thursday) |
9 PM | Away | Wisconsin | Madison, Wis. | FS1 | |||
| March 5, 2023 (Sunday) |
12:30 PM | Home | Illinois | West Lafayette, Ind. | FOX |