| Date | Time | TV | At | Opponent | Location | Result | AP Rank |
| Nov 6 (Mon) | 6:30 PM | BTN | Home | Samford | West Lafayette, Ind. | W 98-45 | 3 |
| Nov 10 (Fri) | 7 PM | B1G + | Home | Morehead State | West Lafayette, Ind. | W 87-57 | 3 |
| Nov 13 (Mon) | 8:30 PM | FS1 | Home | Xavier | West Lafayette, Ind. | W 83-71 | 2 |
| Nov 20 (Mon) | 5 PM | ESPN2 | Neutral | #11 Gonzaga | Honolulu, Hawai’i | W 73-63 | 2 |
| Nov 21 (Tue) | 8 PM | ESPN | Neutral | # 7 Tennessee | Honolulu, Hawai’i | W 71-67 | 2 |
| Nov 22 (Wed) | 5 PM | ESPN | Neutral | #4 Marquette | Honolulu, Hawai’i | W 78-75 | 2 |
| Nov 28 (Tue) | 8:30 PM | BTN | Home | Texas Southern | West Lafayette, Ind. | W 99-67 | 1 |
| Dec 1 (Fri) | 9 PM | BTN | Away | Northwestern | Evanston, Ill. | ||
| Dec 4 (Mon) | 7 PM | BTN | Home | Iowa | West Lafayette, Ind. | ||
| Dec 9 (Sat) | 1:30 PM | FOX | Neutral | Alabama | Toronto, Ontario | ||
| Dec 16 (Sat) | 4:30 PM | Peacock | Neutral | Arizona | Indianapolis, Ind. | ||
| Dec 21 (Thu) | 6:30 PM | BTN | Home | Jacksonville | West Lafayette, Ind. | ||
| Dec 29 (Fri) | 5 or 7 PM | BTN | Home | Eastern Kentucky | West Lafayette, Ind. | ||
| Jan 2 (Tue) | 7 PM | Peacock | Away | Maryland | College Park, Md. | ||
| Jan 5 (Fri) | 8:30 PM | FS1 | Home | Illinois | West Lafayette, Ind. | ||
| Jan 9 (Tue) | 9 PM | Peacock | Away | Nebraska | Lincoln, Neb. | ||
| Jan 13 (Sat) | 2:15 PM | BTN | Home | Penn State | West Lafayette, Ind. | ||
| Jan 16 (Tue) | 7 PM | Peacock | Away | Indiana | Bloomington, Ind. | ||
| Jan 20 (Sat) | 2 PM | FS1 | Away | Iowa | Iowa City, Iowa | ||
| Jan 23 (Tue) | 9 PM | Peacock | Home | Michigan | West Lafayette, Ind. | ||
| Jan 28 (Sun) | 1 PM | FOX | Away | Rutgers | Piscataway, N.J. | ||
| Jan 31 (Wed) | 6:30 PM | BTN | Home | Northwestern | West Lafayette, Ind. | ||
| Feb 4 (Sun) | 1 PM | CBS | Away | Wisconsin | Madison, Wis. | ||
| Feb 10 (Sat) | 8 PM | FOX | Home | Indiana | West Lafayette, Ind. | ||
| Feb 15 (Thu) | 8:30 PM | BTN | Home | Minnesota | West Lafayette, Ind. | ||
| Feb 18 (Sun) | 1 PM | CBS | Away | Ohio State | Columbus, Ohio | ||
| Feb 22 (Thu) | 7 PM | FS1 | Home | Rutgers | West Lafayette, Ind. | ||
| Feb 25 (Sun) | 2 PM | CBS | Away | Michigan | Ann Arbor, Mich. | ||
| Mar 2 (Sat) | 8 PM | FOX | Home | Michigan State | West Lafayette, Ind. | ||
| Mar 5 (Tue) | 7 PM | Peacock | Away | Illinois | Champaign, Ill. | ||
| Mar 10 (Sun) | 12:30 PM | FOX | Home | Wisconsin | West Lafayette, Ind. | ||
| Mar 13 (Wed) | TBA | Peacock | Neutral | Big Ten Tournament First Round | Minneapolis, Minn. | ||
| Mar 14 (Thu) | TBA | BTN | Neutral | Big Ten Tournament Second Round | Minneapolis, Minn. | ||
| Mar 15 (Fri) | TBA | BTN | Neutral | Big Ten Tournament Quarterfinals | Minneapolis, Minn. | ||
| Mar 16 (Sat) | TBA | CBS | Neutral | Big Ten Tournament Semifinals | Minneapolis, Minn. | ||
| Mar 17 (Sun) | TBA | CBS | Neutral | Big Ten Tournament Championship | Minneapolis, Minn |